Histocompatibility Testing in Organ Transplantation
نویسندگان
چکیده
منابع مشابه
Histocompatibility Testing and Organ Sharing
Histocompatibility and its current application in kidney transplantation are discussed. Both theoretic and clinical aspects of human leukocyte antigen testing are described, including antigen typing, antibody detection, and lymphocyte crossmatching. Living related, living unrelated, and cadaveric donor-recipient matching algorithms are discussed with regard to mandatory organ sharing and graft ...
متن کاملHistocompatibility testing for organ transplantation purposes in Albania: a single center experience.
BACKGROUND Histocompatibility testing (HT) which includes donor-recipient human leukocyte antigen (HLA) matching, cross-match testing (XMT) and anti-HLA antibody searching are crucial examinations in solid organ transplantation aiming to avoid the hyperacute graft rejection and also to predict the immunological outcome of the graft. AIMS The aim of this study was to analyse the tissue typing ...
متن کاملProspective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation
Dendritic cells (DC) are rare, professional antigen-presenting cells with ability to induce or regulate alloimmune responses. Regulatory DC (DCreg) with potential to down-modulate acute and chronic inflammatory conditions that occur in organ transplantation can be generated in vitro under a variety of conditions. Here, we provide a rationale for evaluation of DCreg therapy in clinical organ tra...
متن کاملMajor Histocompatibility Complex Class I Chain-Related A (MICA) Molecules: Relevance in Solid Organ Transplantation
An ever growing number of reports on graft rejection and/or failure even with good HLA matches have highlighted an important role of non-HLA antigens in influencing allograft immunity. The list of non-HLA antigens that have been implicated in graft rejection in different types of organ transplantation has already grown long. Of these, the Major Histocompatibility Complex class I chain-related m...
متن کاملChallenges in Organ Transplantation
Organ transplantation has progressed tremendously with improvements in surgical methods, organ preservation, and pharmaco-immunologic therapies and has become a critical pathway in the management of severe organ failure worldwide. The major sources of organs are deceased donors after brain death; however, a substantial number of organs come from live donations, and a significant number can also...
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ژورنال
عنوان ژورنال: Laboratory Medicine
سال: 1999
ISSN: 0007-5027,1943-7730
DOI: 10.1093/labmed/30.12.796